СТАЛЛ Роберт А. (US),ДИЛЛА Скотт Дж. (US),ФУРД Орит (US),ОДЖЕЙ Монетт (US)
申请号：
RU2013113638/10
公开号：
RU2013113638A
申请日:
2011.08.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. An isolated anti-Notum antibody that competes with the hSC2.D2.2 antibody for Notum binding. 2. The anti-Notum antibody of claim 1, comprising a heavy chain and a light chain； wherein the heavy chain comprises a CDR1 region comprising the amino acid sequence of SEQ ID NO: 122, CDR2 including the amino acid sequence of SEQ ID NO: 160, and CDR3 including the amino acid sequence of SEQ ID NO: 198； the light chain contains a CDR1 region including the amino acid sequence of SEQ ID NO: 236, CDR2 including the amino acid sequence of SEQ ID NO: 274, and CDR3 including the amino acid sequence of SEQ ID NO: 312.3. The anti-Notum antibody of claim 2, wherein the heavy chain comprises a variable region including the amino acid sequence of SEQ ID NO: 331, and the light chain contains a variable region including the amino acid sequence of SEQ ID NO: 332.4. The anti-Notum antibody of claim 2, wherein said antibody is an hSC2.D2.2.5 antibody. Antibody according to any one of paragraphs. 1-4, where the specified antibody is conjugated to an antitumor agent. 6. Antibody according to any one of paragraphs. 1-4, where the specified antibody is a chimeric antibody or a humanized antibody. An isolated anti-Notum antibody containing heavy chain CDR1, CDR2 and CDR3 regions and light chain CDR1, CDR2 and CDR3 regions of an antibody selected from antibody SC2.A1, antibody SC2.A3, antibody SC2.A6, antibody SC2.A8, antibody SC2.A11, antibodies SC2.A12, antibodies SC2.A13, antibodies SC2.A101, antibodies SC2.A109, antibodies SC2.A113, antibodies SC2.A106, antibodies SC2.A122, antibodies SC2.10E11, antibodies SC2.9E7, antibodies SC2.A118, SC2.A126 antibodies, SC2.5C4 antibodies, SC2.A110 antibodies, SC2.D1 antibodies, SC2.D3 antibodies, SC2.D4 antibodies, SC2.D7 antibodies, S antibodies1. Изолированное анти-Notum-антитело, которое конкурирует с антителом hSC2.D2.2 за связывание Notum.2. Анти-Notum-антитело по п. 1, содержащее тяжелую цепь и легкую цепь； в которомтяжелая цепь содержит область
