A method for producing an endoplasmic reticulum in which a functioning substance is included into a lipid endoplasmic reticulum having lipids as the main component. This method involves a step (a) for storing the functioning substance lipids and water into a tubular container, and a step (b) for producing the endoplasmic reticulum in which the functioning substance is included into a lipid endoplasmic reticulum having lipids as the main component by kneading the contents stored in the tubular container as a consequence of rotating the tubular container about the central axis thereof and making the tubular container orbit about a predetermined orbital axis.DRAWING: FIG.1 AA Intersection point BB Rotation axis CC Rotation DD Rotation angle velocity EE Orbital axis FF Rotation radius (r) GG Orbit HH Orbital axis velocity II Orbit radius (r)