The present invention relates to the field of bacterial polysaccharide antigenvaccines. In particular, the present invention relates to vaccines comprisinga pneumococcal polysaccharide antigen, typically a pneumococcal polysaccharideconjugate antigen formulated with a protein antigen from Streptococcuspenumoniae selected from the group consisting of PhtA, PhtD, PhtB, PhtE, SpsA,LytB, LytC, LytA, Sp125, Sp101, Sp128, Sp130 and Sp133, and optionally a Th1-inducing adjuvant.