LA MOTTE-MOHS, ROSS,SHAH, KALPANA,SMITH, DOUGLAS H.,JOHNSON, LESLIE S.,MOORE, PAUL A.,BONVINI, EZIO,KOENIG, SCOTT
申请号：
CA2986953
公开号：
CA2986953A1
申请日:
2016.06.07
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention is directed to the anti -LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3 - binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.
