Teizo Fujita,Hans-Wilhelm Schwaeble,Cordula Margaret Stover
申请号：
US15348162
公开号：
US20170127657A1
申请日:
2016.11.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Genetically modified mammals are described which lack the mannan binding lectin associated serine protease MASP-2, together with methods and constructs for their production. Such mammals are useful as models for disorders of the complement system, and in the identification of treatments for such disorders. Also described are mammals which lack the associated protein MAp19； such mammals may also lack MASP-2.
