MARIA SCARSELLI,RINO RAPPUOLI,MARIAGRAZIA PIZZA,MARZIA GIULIANI,VEGA MASIGNANI,FEDERICA DI MARCELLO,DANIELE VEGGI,LAURA CIUCCHI
申请号：
PT05786178
公开号：
PT1784419E
申请日:
2005.09.01
申请国别(地区):
PT
年份:
2013
代理人:
摘要：
'NMB1870' is a known surface protein in Neisseria meningitidis expressed across all serogroups. It has three distinct families. Serum raised against a given family is bactericidal within the same family, but is not active against strains which express one of the other two families i.e. intra-family but not inter-family cross-protection. The inventors have found that NMB1870 can be divided into domains, and that not all domains are required for antigenicity. Antigenic domains can be taken from each of the three NMB1870 families and expressed as a single polypeptide chain. The inventors have also found that NMB1870 exposes some of its epitopes in surface loops situated between alpha helices, and that substitution of loop epitopes from one family into the loop position in another family allows chimeric NMB1870 to be produced with multi-family antigenicity. Thus chimeric NMB1870 proteins are provided that comprise portions of NMB1870 from different families.
