Linker toxin and antibody-drug conjugates combination human tumour antigen target, for example, folacin receptor α and/or provide for microtubulin-resisting pharmaceutical activity disclosure. Connector toxin and antibody-drug conjugates include eribulin pharmaceutical group and can internalization to target antigen expression cell. The disclosure is provided further to the method and composition for treating cancer by the way that the antibody-drug conjugates are administered herein.