JOSEPH L. KIM,NEIL BIFULCO JR.,CHANDRASEKHAR V. MIDUTURU,STEVEN MARK WENGLOWSKY
申请号：
ARP160103546
公开号：
AR106756A1
申请日:
2016.11.18
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
1. Claim 1: a formula compound (1),or a pharmaceutically acceptable salt thereof, characterized in that: ring A is selected from monocyclic or bicyclic aryl, monocyclic or bicyclic heteroaryl, cycloalkyl and heterocyclyl； each RA is independently selected from monocyclic or bicyclic aryl, monocyclic or bicyclic heteroaryl, monocyclic or bicyclic cycloalkyl, monocyclic or bicyclic heterocyclyl, C₁₋₆ alkyl, C₁₋₆ alkoxy, halo, C₁₋₆ haloalkyl, C₁₋₆ haloalkoxy, C₁₋₆ hydroxyalkyl, C₁₋₆ heteroalkyl, -N (R¹) (R¹),nitro ciano -C (O) R-OC (O) R-C (O) OR-SR1,-S (O) R-S (O) -N (R) (R)- (C alquilen) -S (O) -N (R) (R)-C (O) -N (R) (R)-N (R) (R) -C (O) R-(C83218331) 832626 Aussie -N (R Erlang) -C (O) R1,-NR S (O) R-P (O) (R) (R)Y-OR1；a. Each arilo, heteromorphic, cyclopentyl, isomerized, tar, oxygen, halogenated, hydrogenated, isomerized, replaced with 0-5 grade r749191；a. Each RB from c832188331；nitro ciano y -OReach R¹ is independently selected from hydrogen, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ haloalkoxy, C₁₋₆ hydroxyalkyl, C₁₋₆ heteroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl, where each of C₁₋ ₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ hydroxyalkyl, C₁₋₆ heteroalkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl is independently substituted with 0-5 instances of Rᵇ；2. From hydrogen, c832131；each Rᵃ and Rᵇ is independently selected from halo, cyano, hydroxyl, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, -N (R ’’) (R ’’),-C (O) -N (R) (R)-N (R) (R) -C (O) RY - (c832318326 lease) - n (R) - C (o) r '；each R ’and R’ ’is independently selected from hydrogen and C₁₋₆ alkyl or C₁₋₆ hydroxyalkyl； m is 0, 1, 2, 3, 4 or 5； and n is 0, 1 or 2； with the proviso that the compound is not (R) -5- (2- (2,5-difluorophenyl) pyrrolidin-1-yl) pyrazolo [1,5-a] pyrimidin-3-carbonitrile.Reivindicación 1: Un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo, caracterizado porque: el anillo A se selecciona entre arilo monocíclico o bicíclico, hetero
