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Factor VIII variant-expressing vector with increased protein expression capacity
专利权人:
Reyon Pharmaceutical Co., Ltd.;G&P Bioscience Co., Ltd.
发明人:
HO, Seong-Hyun,PARK, Su Jin
申请号:
AU2018379481
公开号:
AU2018379481A1
申请日:
2018.12.05
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present invention relates to an expression vector that carries a polynucleotide coding for a coagulation factor VIII variant and increases protein expression capacity, and a pharmaceutical composition comprising the expression vector for preventing or treating hemorrhagic disease or hemorrhage. The factor VIII variant of the present invention is derived by deleting a part (residues 784-1667) of the B-domain and a part (residues 1668-1671) of the a3 region in factor VIII and, as a result, an expression vector carrying a polynucleotide coding for the factor VIII variant is remarkably increased in protein expression capacity.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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