Factor VIII variant-expressing vector with increased protein expression capacity

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专利权人:

Reyon Pharmaceutical Co., Ltd.;G&P Bioscience Co., Ltd.

发明人:

HO, Seong-Hyun,PARK, Su Jin

申请号：

AU2018379481

公开号：

AU2018379481A1

申请日:

2018.12.05

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention relates to an expression vector that carries a polynucleotide coding for a coagulation factor VIII variant and increases protein expression capacity, and a pharmaceutical composition comprising the expression vector for preventing or treating hemorrhagic disease or hemorrhage. The factor VIII variant of the present invention is derived by deleting a part (residues 784-1667) of the B-domain and a part (residues 1668-1671) of the a3 region in factor VIII and, as a result, an expression vector carrying a polynucleotide coding for the factor VIII variant is remarkably increased in protein expression capacity.

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中国工程科技知识中心

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