ANTIBODY PRODUCING NON-HUMAN MAMMALS COMPRISING A HUMAN IMMUNOGLOBULIN LIGHT CHAIN VARIABLE REGION

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专利权人:

MERUS B.V.

发明人:

HOUTZAGER, ERWIN,PINTO, RUI DANIEL,LOGTENBERG, TON,THROSBY, MARK,KRAMER, ROBERT, ARJEN,DE KRUIF, CORNELIS, ADRIAAN

申请号：

NZ59011809

公开号：

NZ590118A

申请日:

2009.06.29

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

Disclosed is a transgenic non-human mammal comprising, at least in its B cell lineage, a nucleic acid molecule encoding a human immunoglobulin light chain variable region, wherein said light chain variable region is capable of pairing with at least two different heavy chain variable regions encoded by said transgenic, non-human mammal.

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