Synthesis of GLYT-1 Inhibitors

• 收藏
• 分享

专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

CHRISTOPHE PFLEGER,PIUS WALDMEIER,SHAONING WANG

申请号：

BRPI0808570

公开号：

BRPI0808570A2

申请日:

2008.02.25

申请国别(地区):

BR

年份:

2014

代理人:

摘要：

The present invention relates to a process for preparation of a compound of formula I wherein Het, R1, R2, R3, and n are as defined herein and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a compound of formula 21 with a compound of formula 8 to obtain a compound of formula 11 and coupling the compound of formula 11 in the presence of a coupling reagent or the corresponding acid halogenide with a compound of formula 15 to obtain a compound of formula I.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/