University of Florida Research Foundation; Incorporated
发明人:
Robert William Huigens, III,Nicholas G. Paciaroni,Hendrik Luesch
申请号：
US16097167
公开号：
US20190256490A1
申请日:
2017.04.28
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure provides compounds of Formulae (I-A), (II′；), (III-A), (IV′；), and (V-A), wherein the compounds are derived from or based on yohimbine. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, cancers, inflammatory diseases, autoimmune diseases, and infectious diseases) in a subject in need thereof. The present disclosure provides methods of preparing compounds of Formulae (I-A), (II′；), (III-A), (IV′；), and (V-A). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
