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JAK kináz inhibitor biszulfát kristályos alakja és eljárás elõállítására
专利权人:
Jiangsu Hengrui Medicine Co.; Ltd.
发明人:
SUN, Piaoyang,WU, Guaili,ZHANG, Quanliang,CHEN, Yongjiang,SHEN, Lingjia
申请号:
HUE15857844
公开号:
HUE047404T2
申请日:
2015.10.09
申请国别(地区):
HU
年份:
2020
代理人:
摘要:
The present invention relates to a crystal form of JAK kinase inhibitor bisulfate and a preparation method thereof. In particular, the present invention relates to a type II crystal of (3 aR, 5 s, 6 aS ) -N- (3-methoxyl-1,2,4-thiadiazole-5-yl)-5-(methyl(7 H- pyrrolo[2,3- d ]pyrimi dine-4-yl)amino)hexahydrocyclopenta[ c ]pyrrole-2(1 H )-formamide bisulfate and a preparation method thereof. The preparation method comprises crystallizing any crystal forms or amorphous compound of formula (I) solid in a single organic solvent or a mixed organic solvent to obtain a type II crystal form of a compound of formula (I). The type II crystal form of compound of formula (I) obtained by the present invention has a good crystal stability and chemical stability, and the used crystal solvent has a low toxicity and residue, which can be better used in clinical treatment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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