ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN, HO YONG,손호용,KIM, JONG SIK,김종식,SHIN, WOO CHANG,신우창,KIM, MI SUN,김미선,LEE, SANG JIN,이상진
申请号：
KR1020120110958
公开号：
KR1020140044692A
申请日:
2012.10.05
申请国别(地区):
KR
年份:
2014
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a health functional food comprising an extract of Korean rice wine lees as an active ingredient for prevention or treatment of thrombosis and, more specifically, to a pharmaceutical composition and a health functional food comprising, as an active ingredient, an ethanol extract or a hot water extract of Korean rice wine lees, or a mixture thereof, particularly, an ethyl acetate fraction, a butanol fraction, or a water residue of the extract of Korean rice wine lees, or a mixture thereof, for prevention or treatment of thrombosis. The extracts of Korean rice wine lees as an active ingredient of the pharmaceutical composition and the health functional food of the present invention are prepared by performing extraction on Korean rice wine lees using ethanol or the like to prepare an extract and then performing sequential fraction on the extract using hexene, ethyl acetate, and butanol. These extracts have an effect of efficiently inhibiting antithrombotic activity, antiplatelet activity, and thrombosis, due to the direct inhibition of human thrombin, and has an excellent effect of preventing or treating thrombosis, such as ischemic stroke and hemorrhagic stroke, by improving blood circulation. In particular, the extract of Korean rice wine lees of the present invention does not show acute oral toxicity, has excellent thermal stability, and does not show losses due to the direct inhibition of human thrombin, inhibition of prothrombin, and inhibition of blood clotting factors, even in acidic conditions of pH 2 and in the plasma. Therefore, the extract of Korean rice wine lees of the present invention is processed into various forms such as an extract liquid, a powder, a pill, and a tablet, and thus can be taken at all times, so that the present invention is very useful in the pharmaceutical industry and food industry.COPYRIGHT KIPO 2014본 발명은 주박(酒粕) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료용 약학적 조성물 및 건강 기
