The present invention relates to a physiologically active substance complex, a method for producing the same, and a skin whitening function, a wrinkle removing function or a cosmetic composition for preventing skin aging. The present invention provides a complex in which a physiologically active substance is stably complexed with a rare earth hydroxide having a layered structure, and the stability of the physiologically active substance is preserved for a long time even at a high temperature of 50 ° C. or higher. It is useful for cosmetic compositions for skin whitening, wrinkle removal or skin aging prevention, including its neutrality and minimizing potential side effects such as potential toxicity and irritation. is there.本発明は、生理活性物質複合体、その製造方法及びそれを含有する皮膚美白機能、しわ除去機能または皮膚老化防止用の化粧料組成物に関する。本発明は、層状構造の希土類水酸化物に生理活性物質を安定的に複合化した複合体を提供し、前記複合体で生理活性物質が５０℃以上の高温でも長時間にわたって安定性が保存され、ｐＨを中性に維持して潜在的な毒性及び刺激性などの副作用を最小限に抑えることで、それを含む皮膚美白機能、しわ除去機能または皮膚老化防止用の化粧料組成物に有用である。
