A automatically operable clinical oxygen supply device (100) adapted to supply supplemental oxygen to a patient, comprising an oxygen inlet section (110) with a first coupling unit (111) adapted to be releasably coupled to a standardized oxygen wall outlet (1), an oxygen outlet section (120) with a second coupling unit (121) adapted to be releasably coupled to a oxygen dispensing device (2) attached to a patient (3), an oxygen flow control section (130) with a communication unit (111) adapted to receive data from an oxygen saturation sensing device (4) attached to the patient (3), and with a regulation unit (112) adapted to regulate an oxygen flow between the oxygen inlet section (110) and the oxygen outlet section (120) on the basis of data received by the communication unit (111) is provided. The automatically operable clinical oxygen supply device (100) further comprises an energy conversion section (140) adapted to generate electrical energy from pressure energy of oxygen supplied to the oxygen inlet section (110), and an energy supply section (150) adapted to provide the electrical energy generated by the energy conversion section (140) to the oxygen flow control section (130). A clinical oxygen supply system (1) and a method of clinical oxygen supply are also part of the present invention.
