The preparation of poly-2-oxazoline amphiphilic polymers and copolymers is described. Also described are self-assembled particles comprising such amphiphilic polymers and useful for targeted delivery of therapeutic and diagnostic agents. [Selection] Figure 1Aポリ-2-オキサゾリン両親媒性ポリマーおよびコポリマーの調製を記載する。また、このような両親媒性ポリマーを含み、治療用および診断用薬剤の標的化送達に有用な自己集合型粒子も記載する。【選択図】図1A