achieved a stable maintenance and cultivation of \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u043b\u0430\u0441\u0442\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0445 cells created during the process of induction and differentiation of \u043f\u043b\u044e\u0440\u0438\u043f\u043e\u0442\u0435\u043d \u0442\u043d\u044b\u0445 stem cells into hepatocyte. the invention also provides a product cultivation, the \u043a\u0443\u043b\u044c\u0442\u0443\u0440\u0430\u043b\u044c\u043d\u044b\u043c way.these \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u043b\u0430\u0441\u0442\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0435 cells can be stably executed and the cultivation of \u043b\u0430\u043c\u0438\u043d\u0438\u043d\u0430 in contact with \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u043b\u0430\u0441\u0442\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u043c\u0438 cells. method of the invention, which uses the laminin, makes it possible for the first time to cultivate, maintain and proliferate \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u043b\u0430\u0441\u0442\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0435 cells.the desired mature cells such as mature hepatocyte and biliary duct epithelial cells can be generated in a short period of time and can \u043f\u0440\u0438\u043e\u0431\u0440\u0435\u0442\u0430 are you in a \u0442\u0430\u0439\u043c\u0438\u043d\u0433\u0435 maintaining \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u043b\u0430\u0441\u0442\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0445 cells.further, the \u043a\u0443\u043b\u044c\u0442\u0438\u0432\u0438\u0440\u043e\u0432\u0430\u043d\u043d\u044b\u0435 \u0433\u0435\u043f\u0430\u0442\u043e\u0431\u043b\u0430\u0441\u0442\u043f\u043e\u0434\u043e\u0431\u043d\u044b\u0435 cells were shown as capable of inducing differentiation into mature hepatocyte, as capable of industrialization \u0446\u0438\u0440\u043e\u0432\u0430\u0442\u044c in mature hepatocyte, mature \u0445\u043e\u043b\u0430\u043d\u0433\u0438\u043e\u0446\u0438\u0442\u044b, epithelial cells of duct and
