The present disclosure provides methods for treating a cancer patient. The methods rely on the observation that cells of the immune system which target a tumour cell ("effector cells") clonally expand before a population of "regulator" or "suppressor" cells which down-regulate the activity of the immune cells which target the tumour cell. Methods are provided herein which stimulate effector cell production and also provides means for inhibiting the production of, limiting the function of, and/or destroying, regulator cells, in the treatment of cancer.