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New benzenesulfonamides as calcium channel blockers
专利权人:
ABBVIE BAHAMAS LTD.
发明人:
ZHANG, QINGWEI,STEWART, ANDREW,XIA, ZHIREN,JARVIS, MICHAEL F.,SCOTT, VICTORIA E.
申请号:
ES10701070
公开号:
ES2527467T3
申请日:
2010.01.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I) or (II), ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1 is X and R2 is Y; X is (i) or (ii): m and n, in each case, are independently 1 or 2; G1 is azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl or azepanyl, where G1 is connected through the nitrogen atom of said azetidinyl, pyrrolidinyl, piperidinyl, morpholinyl, thiomorpholinyl or azepanyl; Y is -NRcAr1, -NRcAr2-Ar1, -NRcCH (Ar1) 2, -NRc (CRaRb) pAr1, -NRc (CRaRb) pCH (Ar1) 2, -NRc-G2, -NRc-G2-Ar1, (iii) , (iv), (v) or (vi): Ar1, in each case, is independently aryl or heteroaryl, wherein said aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 or 5 substituents selected from alkoxy, alkyl, cyano, haloalkyl, halogen or -N (alkyl) 2; Ar2 is aryl or heteroaryl, wherein said aryl and heteroaryl are unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from alkoxy, alkyl, cyano, haloalkyl or halogen; G2 is cycloalkyl; Ra and Rb are independently hydrogen, alkyl or hydroxyalkyl in each case; Rc is hydrogen or alkyl; p is 1, 2, 3 or 4; and R3, R4, R5 and R6 are each independently hydrogen, alkoxy, alkyl or halogen.Un compuesto de fórmula (I) o (II),**Fórmula** o una sal farmacéuticamente aceptable del mismo, donde R1 es X y R2 es Y; X es (i) o (ii): m y n, en cada caso, son independientemente 1 o 2; G1 es azetidinilo, pirrolidinilo, piperidinilo, morfolinilo, tiomorfolinilo o azepanilo, donde G1 está conectado a través del átomo de nitrógeno de dicho azetidinilo, pirrolidinilo, piperidinilo, morfolinilo, tiomorfolinilo o azepanilo; Y es -NRcAr1, -NRcAr2-Ar1, -NRcCH(Ar1)2, -NRc(CRaRb)pAr1, -NRc(CRaRb)pCH(Ar1)2, -NRc-G2, -NRc-G2-Ar1, (iii), (iv), (v) o (vi): Ar1, en cada caso, es independientemente arilo o heteroarilo, donde dicho arilo y heteroarilo están sin sustituir o sustituidos con 1, 2, 3 o 4 o 5 sustituyentes seleccionados entre alcoxi, alquilo, ciano, haloalquilo, halógeno o -N(alquilo)2; Ar2 es arilo o heteroa
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