LEE, Richard,PATWARI, Parth,LOFFREDO, Francesco,PANCOAST, James
申请号：
ES13808681
公开号：
ES2651113T3
申请日:
2013.06.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A composition comprising at least one HBn-Xn conjugate, in which HB is a heparin-binding peptide selected from KRKKKGKGLGKKRDPRLRKYK (SEQ ID NO: 2), MKRKKKGKGLGKKRDPRLRKYK (SEQ ID NO: 21), KRKKKKKKQ ID: )； or MKRKKKGKGLGKKRDPKLRKYK (SEQ ID NO: 22)； X is an active ingredient selected from: nerve growth factor (NGF)； brain-derived neurotrophic factor (BDNF)； neurotrophin-3 (NT-3)； neurotrophin-4 (NT-4)； ciliary neurotrophic factor (CNTF)； astrocyte-derived mesencephalic neurotrophic factor (MANF)； neurotrophic conserved dopamine factor (CDNF)； ligands of the neurotrophic factor family derived from the glial cell line； neurotrophic factor derived from the glial cell line (GDNF)； neurturin (NRTN)； Artemina (ARTN)； persephin (PSPN)； neuropoietic cytokines selected from interleukin-6, interleukin-11, interleukin-27, leukemia inhibitor factor, ciliary neurotrophic factor, cardiotrophin 1, neuropoietin, cardiotropin-like cytokine or fibroblast growth factor 2； anti-inflammatory cytokines selected from interleukin-4 and interleukin-10 from TNF receptor 2； neurregulin-1 and vascular endothelial growth factor (VEGF)； Cerebrolysin® (FPF-1070)； growth differentiation factor 11 (GDF11)； stromal cell derivative factor 1 (SDF-1)； myostatin (fibroblast growth differentiation factor 8 (GDF8))； insulin type growth factor 1 (IGF1)； parathyroid hormone (HPT)； a portion of the PTH, selected from amino acid residues 1-31,1-34 (TM Forteo ®), 1-37, 1-38, 1-44, or 1-84 of the mature PTH； parathyroid hormone-related peptide (PTHrP) or a PTHrP analog having the sequence (AVSEHQLLHDKGKSIQDLRRRELLEKLLNKLHTA, where N is Aib (2-aminoisobutyric acid) (SEQ ID NO: 39), interleukin 1 receptor antagonist (IL-1) IRA)； chimeras IL-1 / IL-1 RA, IL-1RA polypeptide having the amino acid sequence: RPSGRKSSKMQAFRIWDVNQKTFYLRNLVAGYLQGPNVNLEEKIDVVPIEP HALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSF ESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE (SEQ ID NO: 40), factor 18, fibroblast growth (FGF-18)； prote
