The present invention relates to a magnetic nanoparticle for tumor therapy, comprising: a magnetic core a shell encapsulating a surface of the magnetic core, wherein the shell is made of a polymer with carboxylic groups a poly-nucleotide chain connected to a surface of the shell an anti-tumor drug connected to the poly-nucleotide chain, wherein the anti-tumor drug comprises at least one functional group, and each of the functional group is independently a pyrimidine group or a purine group and an antibody connected to the shell, wherein the antibody identifies a target tumor. In addition, the present invention further provides a method for manufacturing the magnetic nanoparticles for tumor therapy and a pharmaceutical composition containing the magnetic nanoparticles. Accordingly, the magnetic nanoparticle for tumor therapy of the present invention can achieve effective treatment of tumor by synergistic effects between hyperthermia and targeted chemotherapy.
