Simona M. Ceccarelli,Ravi Jagasia,Roland Jakob-Roetne,Juergen Wichmann
申请号：
US14723061
公开号：
US09315502B2
申请日:
2015.05.27
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to compounds of general formulawhereinAr is phenyl or pyridinyl；X1 is N or CH,X2 is N or CH, with the proviso that only one of X1 or X2 is N and the other is CH；R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, cyano or S(O)2-lower alkyl；R2 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen or cyano；n is 1 or 2；or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof.The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.
