Paolo Costantino,Francesco Berti,Francesca Micoli,Anna Kabanova,Laura Serino,Maria Rosaria Romano,Marta Tontini
申请号：
US13520338
公开号：
US09173954B2
申请日:
2010.12.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
E. coli proteins have been identified that are useful as carrier proteins to improve a response to a polysaccharide immunogen conjugated to such protein. In particular, AcfD precursor protein (orf3526 polypeptide), Flu antigen 43 protein (orf1364 polypeptide), and Sel1 repeat-containing protein (upec-5211 polypeptide) have been shown to be effective. Additionally, these E. coli proteins can enhance the immune response to glucans, particularly fungal glucans.
