The invention relates to the use of at least one amino acid, selected from the group of histidine, lysine, and threonine in the manufacture of a composition for use in the treatment of a pervasive development disorder, a neurogenetic syndrome associated with a pervasive development disorder or a symptom of a pervasive development disorder. The invention further relates to a food product comprising histidine, lysine, and/or threonine, to a supplement comprising histidine, lysine, and/or threonine and to a kit of parts comprising histidine, lysine, and/or threonine.