The invention is related to a procine circovirus type 2 (PCV2) immunogenic composition comprising an antigenic peptide. The antigenic peptide is a non-arginine-rich peptide of PCV2 open reading frame 2 (ORF2) and/ or a recombinant fusion protein that is a construction of the non-arginine-rich peptide of PCV2 ORF2, a PE peptide, and a KDEL signal peptide. The arginine numbers of the non-arginine-rich peptide of PCV2 ORF2 are not more than half of the arginine numbers of the arginine-rich domain of the N terminal of PCV2 ORF2.