PURPOSE: A method for screening harmful materials using Drosophila is provided to simply screen toxicity of chemicals which cause pollution of indoor.CONSTITUTION: A harmful material of indoor atmosphere is screened using mutant Drosophila. The mutant Drosophila is prepared by HSP(heat shock protein), xenobiotic metabolism, oxidative stress, stress-associated signaling, or immune response-associated gene deletion. A method for diagnosing toxicity of indoor atmosphere comprises: a step of exposing imago of Drosophila wild type and mutant type to volatile harmful chemical and a step of comparing reaction between the wild type and mutant type 12-72 hours after exposure.COPYRIGHT KIPO 2012초파리를 이용한 실내 대기 유해물질의 스크리닝 방법이 개시되어 있다. 본 발명의 방법에 따르면, 적은 비용과 쉬운 테크닉으로 실내 대기를 오염시키는 유해화학물질의 독성을 간편하게 스크리닝할 수 있다.