Formulated compounds are inhibitors of sodium and calcium (NCX) exchangers,In particular, the sodium and calcium exchanger in subtropical zone 1 (NCX1),They are suitable for the treatment of various disorders, such as arrhythmias, heart failure and ictus, in which the homeostasis of intracellular calcium changes. This document also refers to the preparation procedure of formula compound in Item (1),a. Used as an ingredient of a drug or a constituent drug. 1. Claim 1: a formula compound (1),Any stereo form or any proportion of stereo mixture, or a salt with acceptable efficacy, select ar from 5 or 6 members of phenyl series and single ring aromatic cycle, 1. All of them have not been replaced or replaced by one or more equivalent or different R1 substitutes. Among these substitutes, heterocycle includes one or two equivalent or different ring atoms selected from nitrogen, oxygen and sulfur series and connected with ring carbon； R1 chooses from them Sequence of halogens1. Lease land No. c833218331 and 832626；C₃₋₇ cycloalkyl,C₃₋₇-C₁₋₄- cycloalkyl alkyl,Phoeniclo, hetti 1,I...-C₁₋₆-O-C₃₋₇-O- cycloalkyl,-C₃₋₇-C₁₋₄-C- alkylcycloalkyl,That's it.Het1-o - and c832131 asphalt； 832626-s (o) 8345； -,and two R¹ groups linked to adjacent ring carbon atoms in Ar, together with the carbon atoms that carry them, can form a 5-membered or 7-membered monounsaturated ring comprising 0, 1 or 2 same or different ring heteroatoms selected from the series consisting of nitrogen, oxygen and sulfur, and which are unsubstituted or substituted with one or more same or different substituents selected from the series consisting of fluorine and C₁₋₄ alkyl；R2 was selected from r830909-n (r8310a) - C (o) series；R -N (R) -CH -e. R8311c-c (o) - nh-ch832220 - and r8311l-s (o) c8332222 -；R³ is selected from the series consisting of hydrogen, halogen, C₁₋₄ alkyl and C₁₋₄-O- alkyl；R⁴ is hydrogen or one or more same or different substituents selected from the series consisting of halogen, C₁₋₄ alkyl and C₁
