MAISEL, KATHARINA,ENSIGN, LAURA,HANES, JUSTIN,CONE, RICHARD
申请号：
CA2974715
公开号：
CA2974715A1
申请日:
2016.01.26
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (CGC) under isotonic conditions. The hypotonicity of the formulation is adjusted so that the polymer gels at the lower concentration. A Poloxamer gel administered into the vagina or colorectum at its CGC will form a "plug" of gel in the lumen.
