The current diffusion shows that it is an effective component of cycloketoproteinase inhibitor. Pharmaceutical ingredients. Treatment. 1. Claim 1: compound according to formula (1),Or a pharmaceutically acceptable salt, wherein R1 is defined according to (a) or (b) as follows: (a) R1 has a formula (2), wherein het is isomerized, including 5-6 atoms in the ring, at least one of which is a nitrogen atom selected from n (H),-N (m) - o-n (lease c833218331-83323) -,There, the nitrogen atom on the ring is replaced by an R1 groupthus forming a quaternary nitrogen atom and where the positive charge associated with the quaternary nitrogen atom is balanced by a pharmaceutically acceptable anion； and M is C₁₋₁₂ alkyl；O (b) r 1 is heteromorphic, including 5-6 atoms in the ring, at least one atom in the ring is the nitrogen atom selected from = n-y-n (coke tar c83321331)；And the nitrogen atom on the ring was replaced by an R1 groupThus, a fourth-generation nitrogen atom is formed, and the positive and negative charges related to the fourth-generation nitrogen atom are balanced by a medically acceptable anion； R2 and R3,Add the carbon atoms connected to each person to form a ring； or R2,R83088 and r83099；Combined with carbon atoms, they form a carbon group； or r830808 and r83099；They combine with carbon atoms to form R1 cube；RS1,RS2,RS3,and RS⁴ each is independently selected from C₁₋₆ alkyl,C₁₋₆ hydroxyalkyl,alcoxi C alquilo Caryl C₆₋₁₀,and aralkyl C₇₋₁₂,Each of these alternatives is replaced by a selected group of substances, including: Amida, Amina, carboxyl acid, or a pharmaceutically acceptable salt, carbamate, thioether, and thioether of these substances； RN1,RN,RN-3H rn830808 and rn830808 are selected from between H and r1830808 respectively；R1 is a kind of residual substance that can be removed from pH gt； 7 kinds can be removed from the surface of mat； R2 2 is a polishing group； R3 is a kind of masked carbide that can be removed from pH lt； 6.5 is a kind of enzyme or a
