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透皮遞送系統
专利权人:
LTS Lohmann Therapie-Systeme AG
发明人:
Thomas Hille,Gabriel Wauer,Frank Seibertz,Shun-Lun Weinheimer
申请号:
HK16110445.2
公开号:
HK1222135A
申请日:
2016.09.01
申请国别(地区):
HK
年份:
2017
代理人:
摘要:
The invention relates to transdermal therapeutic system for the transdermal administration of buprenorphine, comprising a buprenorphine-containing selfadhesive layer structure comprising A) a buprenorphine-impermeable backing layer, and B) a buprenorphine-containing pressure-sensitive adhesive layer on said buprenorphine-impermeable backing layer, the adhesive layer comprising a) at least one polymer-based pressure-sensitive adhesive, b) an analgesically effective amount of buprenorphine base or a pharmaceutically acceptable salt thereof, c) a viscosity-increasing substance in an amount of about 0.1% to about 8% of said buprenorphine-containing pressure-sensitive adhesive layer, and d) a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid and mixtures thereof, in an amount sufficient so that said analgesically effective amount of buprenorphine is solubilized therein to form a mixture including said viscositiy-increasing substance, and wherein the carboxylic acid-, buprenorphine- and viscosity-increasing substance-containing mixture forms dispersed deposits in the said pressure-sensitive adhesive, and wherein said buprenorphine-containing pressure-sensitive adhesive layer is the skin contact layer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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