PURPOSE: A composition for preventing acetaldehyde induced diseases, hangover prevention, and hangover curing is provided to rapidly metabolize acetaldehyde which is cause for various diseases and hangover.CONSTITUTION: A composition for preventing acetaldehyde induced diseases, hangover prevention, and hangover curing includes acetaldehyde dehydratase activator, mitochondria activator, anti-oxidant and cell death inhibitor. The acetaldehyde dehydratase activator is salt of calcium ion, magnesium ion, glutamate, L-cysteine or the salt thereof. The mitochondria activator is succinic acid, and glutamate or the salt thereof. The anti-oxidant is silymarin (in other words, milk thistle extract), catechin (in other words, green tea extract), vitamin C, thiamin, B2, B3, B4, B5, B6, B7, B8, B9 or B12. The cell death inhibitor is magnesium ion and creatine or the salt thereof. The composition includes silymarin (in other words, the milk thistle extract) or catechin (in other words, green tea extract) as an anti-oxidant.COPYRIGHT KIPO 2013본 발명은 알콜의 섭취로 인해 발생하는 숙취 및 여러 질환의 원인인 아세트알데하이드를 빠르게 대사시키고, 알콜의 세포내 침투에 의해 발생하는 미토콘드리아의 손상에 의한 세포사멸을 방지하여 몸을 보호하는 효과가 우수한 숙취예방, 숙취해소 및 기타 해당 독소로 인한 부작용 및 질병 예방용 조성물을 제공한다.