Ananda M. Chakrabarty;Arsenio M. Fialho;Tohru Yamada;Tapas K. Das Gupta;Chang Soo Hong
发明人:
Chang Soo Hong,Tohru Yamada,Arsenio M. Fialho,Tapas K. Das Gupta,Ananda M. Chakrabarty
申请号：
US12897298
公开号：
US08188251B2
申请日:
2010.10.04
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention discloses methods and materials for delivering a cargo compound into a brain cancer cell and/or across the blood-brain barrier. Delivery of the cargo compound is accomplished by the use of protein transport peptides derived from Neisseria outer membrane proteins, such as Laz. The invention also provides synthetic transit peptides comprised of the pentapeptide AAEAP (SEQ ID NO: 25). The invention further discloses methods for treating cancer, and specifically brain cancer, as well as other brain-related conditions. Further, the invention provides methods of imaging and diagnosing cancer, particularly brain cancer.
