Dong Hee Lee,Bum Chan Park,Jae Eun Park,Myeong Hee Jang,Seok Ho Yoo,Hye Nan Kim
申请号：
US14370341
公开号：
US09388223B2
申请日:
2013.01.03
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a myostatin inhibitor comprising extracellular water-soluble domains of delta-like 1 homolog (DLK1) as active ingredients. More particularly, the present invention relates to a composition for inhibiting myostatin activity, comprising, as active ingredients, extracellular water-soluble domains of DLK1 or a deletion mutant of extracellular water-soluble domains of DLK1. The myostatin inhibitor of the present invention is bonded to the myostatin or activin receptor type IIB so as to inhibit the action mechanism of the myostatin, to thereby promote myogenesis and prevent differentiation into fat cells. Therefore, the myostatin inhibitor of the present invention may be used in preventing and treating diseases such as muscular dysplasia that requires differentiation to muscular cells, or metabolic diseases.
