БАРР Кеннет Джей (US),БЕЙНСТОК Кори (US),МАКЛИН Джон (US),ЧЖАН Хунцзюнь (US),БЕРЕЗИС Ричард Томас (CN),ЭНТОНИ Невилл (US),ЛАПОЙНТ Блэйр (US),ШАММЕТТА Нунцио (US)
申请号：
RU2015108935
公开号：
RU2015108935A
申请日:
2013.08.14
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A compound of formula I or a pharmaceutically acceptable salt or solvate thereof, wherein Y is CH, N or CR； n = 0, 1, 2, 3 or 4； Represents CR or N, A represents CR or N, A represents CR or N, A represents CR or N, provided that no more than two of A-A may be N； R represents (C) alkyl； R represents (i) (C) carbocyclyl； or (ii) a 4-12 membered heterocyclyl, and both (i) and (ii) are optionally substituted with one, two, three, four, or five R； R is hydroxycarbonyl, hydroxycarbonyl (C) alkyl, (C) alkylsulfoxyaminocarbonyl or carbamoyl； R is hydrogen, halogen, cyano, nitro, hydroxy, (C) alkylC (O) O-, (C) alkyl or (C) alkoxy, wherein (C) alkyl and (C) alkoxy are optionally substituted with one or more halogens； R, R , R and R independently represent H, halogen, amino, cyano, hydroxy, (C) alkoxy, (C) alkyl, (C-) alkyl) aminocarbonyl, (di) (C) alkylaminocarbonyl or amino (C) alkyl, wherein (C) alcohol B, (C) alkyl, (C-) alkyl) aminocarbonyl, (di) (C) alkylaminocarbonyl or an amino (C) alkyl optionally substituted with one or more halogens, hydroxyl groups or (C) alkoxy； or a group having the formula optionally substituted with one or more of the following: (C) alkyl, halogen, amino, cyano, hydroxy, (C) alkoxy, and where m = 1, 2, 3 or 4； R represents halogen, cyano, amino , nitro, hydroxy, HNC (O) -, (C) alkoxycarbonyl, (di) (C) alkylaminocarbonyl, (C) alkyl, (C) cycloalkyl, (C) heterocycloalkyl, (C) heteroaryl or (C) alkoxy, wherein (C) alkoxycarbonyl, (di) (C) alkylaminocarbonyl, (C) alkyl, (C) cycloalkyl and (C) alkoxy are optionally substituted with one, two or three halogens； and R represents hydrogen or (C) alkyl. 2. A compound according to claim 1, having the formula Ia or a pharmaceutically acceptable salt or solvate thereof. 3. A compound according to claim 1, having the formula Ib or a pharmaceutically acceptable salt or solvate thereof. The compound of claim 3, wherein Y is N.5.1. Соединение формулы Iили его фармацевтически приемлемая соль или сольват,где Y
