PROBLEM TO BE SOLVED: To provide a formulation that can improve the solubility in a solution at a low temperature and/or does not accompany incompatibility and maintains a clear solution even under a long-term storage in compounding with fusion, for tformulations for injection that contains sivelestat sodium salt or its hydrate.SOLUTION: The formulation for injection that contains a sivelestat sodium salt, its hydrate and hydrogen carbonate is a formulation having improved solubility in the solution at the low temperature, and further a formulation maintaining the clear solution state without being accompanied with a change in formulation even under preservation over a long period of time when formulated with a transfusion, and which is very easily handled on a medical treatment site.COPYRIGHT: (C)2013,JPO&INPIT【課題】シベレスタットナトリウム塩又はその水和物を含有する注射用製剤について、低温における溶解液への溶解性を向上させ、及び/又は輸液と配合した際に長時間保存下においても配合変化を伴わず、澄明な溶液状態を維持しうる製剤を提供すること。【解決手段】シベレスタットナトリウム塩及びその水和物、及び炭酸水素塩を含有する注射用製剤は、低温における溶解液に対する溶解性が向上した製剤であり、さらに輸液との配合下、長時間を経ても配合変化を伴わず澄明な溶液状態を維持する製剤であって、医療現場において非常に取り扱い易い製剤である。【選択図】なし
