POLYAK, KORNELIA,SHU, SHAOKUN,LIN, CHARLES YANG,BRADNER, JAMES E.
申请号：
CA2995374
公开号：
CA2995374A1
申请日:
2016.08.10
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present disclosure provides combination therapy comprising a BET inhibitor and a protein phosphatase 2A (PP2A) activator, a B-cell lymphoma-2 (Bcl-2) inhibitor, a B-cell lymphoma-extra large (Bcl-xl) inhibitor, a casein kinase 2 (CK2) inhibitor, and/or a mediator complex subunit 1 (MEDl) for cancer. The combination therapy is expected to be synergistic in treating the cancer, compared to the monotherapy. Methods for identifying a subject having a cancer that is resistant to or at risk of developing resistance to bromodomain and extra terminal (BET) inhibitor therapy are also provided.
