The physiological monitoring device, system, and method disclosed herein is convenient and comfortable to use in the detection of physiological health risks. Embodiments may be coupled to a users body at one instead of at multiple locations. Also, embodiments may be calibrated to the individual users to minimize the occurrence of false alarms while remaining sensitive enough to detect true physiological risk events. Physiological parameters that are monitored may include of heart rate, heart rate variability, respiration, perspiration, skin temperature, difference between skin and ambient temperatures, motoric activity, and electrical activity in muscles.