The invention provides interfering ribonucleic acid (RNA)-containing cell particles, and a medicinal composition and a kit containing the interfering RNA-containing cell particles. Through the interfering RNA-containing cell particles and the medicinal composition and the kit containing the interfering RNA-containing cell particles, the effect of the interfering RNA on acceptor cells can be researched, and the interfering RNA can be stably, efficiently and specifically conveyed to treat related diseases. Meanwhile, the invention also provides a method for preparing the interfering RNA-containing cell particles and the medicinal composition and the kit containing the interfering RNA-containing cell particles.