CHRISTOPH HEUSSER,CHRISTOPH SCHWAERZLER,DANIELA DELLA DUCATA,JOSÉ M. CARBALLIDO HERRERA,MICHAEL BARDROFF,UTE JAEGER
申请号：
BRPI1016055
公开号：
BRPI1016055A2
申请日:
2010.03.29
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
The present invention relates to antibodies that specifically bind to IL12R&bgr；1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12R&bgr；2 chain) as well as IL23 receptor (together with IL23R&alpha； chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFN&gamma； production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFN&gamma； production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
