The objective of the present invention is to provide a pharmaceuticalcomposition and a therapeutic method that are specifically effective againstat least onedisease selected from the group consisting of multiple endocrine neoplasia,type IIA,multiple endocrine neoplasia, type IIB, familial medullary thyroid carcinoma,thyroidcarcinoma, papillary thyroid carcinoma, sporadic medullary thyroid carcinoma,Hirschsprung disease, pheochromocytoma, parathyroid hyperplasia and mucosalneuromas of the gastrointestinal tract.4-(3 -chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and analogs thereof are specifically effective against at leastone diseaseselected from the group consisting of multiple endocrine neoplasia, type IIA,multipleendocrine neoplasia, type IIB, familial medullary thyroid carcinoma, thyroidcarcinoma,papillary thyroid carcinoma, sporadic medullary thyroid carcinoma,Hirschsprung disease,pheochromocytoma, parathyroid hyperplasia and mucosal neuromas of thegastrointestinal tract.
