Novel compounds for the modulation of the activity of the orphan gamma receptor (ROR gamma, NR1F3) related to RAR of the orphan nuclear receptor and for the treatment of chronic autoimmune and inflammatory disease
KINZEL, OLAF,STEENECK, CHRISTOPH,KLEYMANN, GERALD,ALBERS, MICHAEL,HOFFMANN, THOMAS,KREMOSER, CLAUS,PEROVIC-OTTSTADT, SANJA,SCHLÜTER, THOMAS
申请号：
ES11706184
公开号：
ES2474166T3
申请日:
2011.02.28
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
Compound represented by formula (1) ** Formula ** and the enantiomers, diastereomers, tautomers, solvates and pharmaceutically acceptable salts thereof, in which: R1 is hydrogen； C1.42 alkyl； C1..12 alkenyl； C1-12 alkynyl； C3-10 cycloalkyl； COO-Ci_6 alkyl； C0NR10R11； CN； NR1 ° R11； a saturated 3-10 membered heterocycle containing 1 or 2 heteroatoms independently selected from the group consisting of N, 0 and S； a 5-10 membered mono or bicyclic heteroaromatic ring system containing 1, 2, 3 6 4 heteroatoms independently selected from the group consisting of N, 0 and S； or a 6-10 membered mono or bicyclic aromatic ring system in which the alkyl, alkenyl, alkynyl, cycloalkyl and heterocyclic groups are not substituted or substituted with 1, 2 or 6 3 substituents independently selected from the group consisting of hydroxyl , oxo, halogen °, cyano, halo-C1_6 alkyl, 0-Ct.6 alkyl, 0- (halo-C1.6 alkyl), C0NR 10R11 and NR10R11； and wherein the heteroaromatic and aromatic ring systens, independently of one another, are not substituted or substituted with 1, 2 or 3 substituents independently selected from the group consisting of hydroxyl, oxo, halogen, cyano, C1_6 alkyl, halo- C1-12 alkyl, C3-6 cycloalkyl, 0- Ci_6 alkyl, 0- (halo-C1_6 alkyl), COOH, CO2NR10R11, NR10 .-. 11, a 5-10 membered mono or bicyclic heteroaromatic ring system containing 1 , 2 6 3 heteroatoms independently selected from the group consisting of N, 0 and S, a 6-10 membered mono or bicyclic aromatic ring system, and a 3-8 membered saturated heterocycle containing 1 02 heteroatoms independently selected from the group which consists of N, 0 and S in which the ring systems, the alkyl and cycloalkyl groups, independently of each other, are not substituted or substituted with 1, 2 or 3 substituents selected from the group consisting of hydroxyl, oxo, halogen °, cyan or, Ci.6 alkyl, halo- C1-6 alkyl, 0-Ci_6 alkyl, 0- (halo-Ci_6 alkyl) and COOH； or wherein the heteroaromatic and aromatic ring systens are condensed
