System and method for estimating a physiological parameter of an elementary volume. The invention relates to a system and a method for producing an estimation of a physiological parameter of an elementary volume - termed a voxel - of an organ. Said method is implemented by processing means of a processing unit (4) of a magnetic resonance imaging analysis system, and comprises a step (230) for estimating said physiological parameter, said step (230) for estimating the physiological parameter consisting in producing the estimated value of said physiological parameter on the basis of the respective prior estimations of first and second physiological parameters.