ЗЭ ГАВЕРМЕНТ ОФ ЗЭ ЮНАЙТЕД СТЭЙТС ОФ АМЕРИКА ЭС РЕПРЕЗЕНТЕД БАЙ ЗЭ СЕКРЕТАРИ ОФ ЗЭ АРМИ (US)
发明人:
АЛВИНГ Карл Р. (US),БЭК Золтан (US)
申请号：
RU2016141622
公开号：
RU2016141622A
申请日:
2015.03.25
申请国别(地区):
RU
年份:
2018
代理人:
摘要：
Provided herein is an adjuvant formulation comprising a monophosphoryl lipid A (MPLA)-containing liposome composition to saponin (e.g., QS-21), wherein the liposome composition comprises i) a lipid bilayer comprising phospholipids in which the hydrocarbon chains have a melting temperature in water of ≧23° C. and ii) cholesterol at a mole percent concentration of greater than about 50% (mol/mol), preferably about 55% to about 71% (mol/mol), or more preferably about 55% (mol/mol). The adjuvant formulation displays minimal toxicity of either lipid A or saponin.
