As for this invention, the below-mentioned general formula (1) Ar-CO-AA1-AA2-AA3-AA4-NH-X-NR1R2 (1)(In formula, as for Ar, showing the phenyl group or aromatic complex cyclic basis which is good possessing the substituent: As for AA1, showing hydrophobic amino acid: As for AA2, the carbon atom showing the amino acid which does not possess the substituent which 2 or more is contained: As for AA3, the carbon atom showing the amino acid which does not possess the substituent which 2 or more is contained: As for AA4, showing hydrophobic amino acid: As for X, from carbon count 2 showing saturation aliphatic hydrocarbon radical of 2 value of 6: R1 and R2, equality or becoming independent respectively, saturation of 8 or showing the unsaturated aliphatic hydrocarbon radical from carbon count, or 1 the nitrogen atom which these R1 and R2 adjoin and becoming simultaneous it is possible to form ring.)So it regards chemical compound or that salt, or those solvent dishes dressed with sauce which are displayed. In addition, this invention, are displayed with the aforementioned general system (1) chemical compound, that salt or those solvent dishes dressed with sauce, and the carrier which on the medicine manufacture is allowed and consists of, it regards the medicine composition in order it prevents & to remedy the disease where PAR-2 participates.本発明は、下記の一般式(1)Ar-CO-AA1-AA2-AA3-AA4-NH-X-NR1R2 (1)(式中、Arは、置換基を有しても良いフェニル基又は芳香複素環式基を示し:AA1は、疎水性アミノ酸を示し:AA2は、炭素原子を2個以上含有する置換基を有さないアミノ酸を示し:AA3は、炭素原子を2個以上含有する置換基を有さないアミノ酸を示し:AA4は、疎水性アミノ酸を示し:Xは、炭素数2から6の2価の飽和脂肪族炭化水素基を示し:R1及びR2は、同一又はそれぞれ独立して炭素数1から8の飽和又は不飽和の脂肪族炭化水素基を示すか、これらのR1及びR2が隣接する窒素原子と一緒になって環を形成してもよい。)で表される化合物若しくはその塩、又はそれらの溶媒和物に関する。また、本発明は、前記一般式(1)で表される化合物、その塩又はそれらの溶媒和物、及び製薬上許容される担体とからなる、PAR-2が関与する疾患を予防・治療するための医薬組成物に関する。
