Postech Academy-Industry- Foundation;Genexine, Inc.
发明人:
Sung, Young Chul,Yang, Sehwan
申请号：
ES12198380
公开号：
ES2623925T3
申请日:
2008.05.30
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A chimeric polypeptide that is a fusion comprising (i) an IgG-IgD hybrid polypeptide and (ii) a polypeptide, a protein or a peptide fused at the N-terminus or the C-terminus of the IgG-IgD hybrid polypeptide, in which ( i) the IgG-IgD hybrid polypeptide is represented by the following formula: N '- (Z1) PY-Z2-Z3-Z4-C' in which: N 'is the N-terminus and C' is the C-terminus of the polypeptide . Z1 is an amino acid sequence consisting of 5 to 9 consecutive amino acid residues from the C-side side of the amino acid sequence at positions 90 to 98 of SEQ ID NO: 14； And it is an amino acid sequence consisting of 5 or more consecutive amino acid residues from the C-side of the amino acid sequence at positions 99 to 162 of SEQ ID NO: 14； Z2 is an amino acid sequence consisting of 4 to 37 consecutive amino acid residues on the N-side of the amino acid sequence at positions 163 to 199 of SEQ ID NO: 14 Z3 is an amino acid sequence consisting of 73 to 106 consecutive amino acid residues on the C-side of the amino acid sequence at positions 115 to 220 of SEQ ID NO: 13； Z4 is an amino acid sequence consisting of amino acid residues at positions 221 to 327 of SEQ ID NO: 13； and p is an integer of 0 or 1； and wherein (ii) the polypeptide, protein or peptide is a hormone, cytokine, growth factor, costimulatory molecule, hormonal receptor, cytokine receptor, growth factor receptor or short peptide.Un polipéptido quimérico que es una fusión que comprende (i) un polipéptido híbrido IgG-IgD y (ii) un polipéptido, una proteína o un péptido fusionado en el extremo N o el extremo C del polipéptido híbrido IgG-IgD, en el que (i) el polipéptido híbrido IgG-IgD se representa por la siguiente fórmula: N'-(Z1)P-Y-Z2-Z3-Z4-C' en la que: N' es el extremo N y C' es el extremo C del polipéptido. Z1 es una secuencia de aminoácidos que consta de 5 a 9 restos de aminoácidos consecutivos procedentes del lado del extremo C de la secuencia de aminoácidos en las posiciones 90 a 98 de la SEQ ID NO: 14； Y e
