가천대학교 산학협력단;GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
KHANG, DONG WOO,강동우,LEE, YEON KYUNG,이연경,KIM, SANG WOO,김상우,HONG, JEONG HEE,홍정희,CHOI, YONG HYUN,최용현,PARK, JUN YOUNG,박준영,KHANG, DONG WOOKR,LEE, YEON KYUNGKR,KIM, SANG WOOKR,HONG, JEONG HEEKR,CHOI, YONG HYUNKR,PARK, JUN YOUNGKR
申请号：
KR1020170051864
公开号：
KR1020180118475A
申请日:
2017.04.21
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention provides a method for manufacturing a stem cell-nano-anticancer drug complex. It is possible to overcome conventional stem cell adverse effects and nano-anticancer drug targeting limitations. Carbon nanotubes (CNTs) and gold (Au) nanoparticle-based anticancer drug is loaded on the surface of a stem cell having an excellent anticancer effect. The method includes a carboxylation step； an {1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide} linker binding step: an anticancer compound and antibody binding step； and a stem cell binding step.본 발명은 기존의 줄기세포 부작용 및 나노 항암제의 표적 한계성을 극복하고 항암제효과도 매우 우수한 줄기세포 표면에 탄소 나노튜브(CNT) 및 금(Au) 나노입자 기반의 항암제가 적재된 줄기세포-나노 항암제 복합체의 제조방법을 제공한다.
