PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating cancer by finding out a novel target gene for cancer treatment, which is a gene which inhibits proliferation of cancer cells by inhibiting an expression or function thereof to enable cancer treatment.SOLUTION: The invention relates to a pharmaceutical composition for cancer treatment which contains a substance inhibiting an expression of Arl4c genes or a substance inhibiting an activity of Arl4c proteins, and to a screening method of the substance for cancer treatment which uses the expression of the Arl4c genes or the activity of the Arl4c proteins as an indicator, and uses the substance inhibiting the expression or activity as a candidate compound.COPYRIGHT: (C)2016,JPO&INPIT【課題】新規な癌治療のターゲット遺伝子、すなわちその発現を抑制又はその機能を抑制することで癌細胞の増殖を抑制し、癌の治療を可能とする遺伝子を見出して、癌の治療用医薬組成物を提供すること。【解決手段】Arl4c遺伝子の発現を抑制する物質又はArl4cタンパク質の活性を抑制する物質を含む、癌の治療のための医薬組成物、ならびに、Arl4c遺伝子の発現又はArl4cタンパク質の活性を指標とし、発現の抑制又は活性の抑制をする物質を候補化合物とする、癌の治療のための物質のスクリーニング方法。【選択図】なし
