The present disclosure relates to 4'-azido, 3'-deoxy-3'-fluoro substituted nucleoside derivatives as inhibitors of HCV replicon RNA replication. Also disclosed are pharmaceutical compositions comprising such compounds and methods of use thereof for the treatment of HCV.La presente invención se refiere a derivados de nucleósidos 4´-fluoro-2´-metilo sustituidos, composiciones farmacéuticas de los mismos, y métodos para usar tales compuestos y/o composiciones de los mismos para el tratamiento de HCV.