RABADAN, RAUL,KRASNITZ, MICHAEL,ROBINS, HARLAN,WITTEN, DANIELA,LEVINE, ARNOLD
申请号：
CA2657626
公开号：
CA2657626C
申请日:
2007.07.12
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The invention relates to inhibitory nucleotide signal sequences or "INS"sequences in the genomes of lentiviruses.In particular the invention relates to the AGG motif present in all viralgenomes. The AGG motif may have an inhibitory effect on avirus, for example by reducing the levels of, or maintaining low steady-statelevels of, viral RNAs in host cells, and inducing and/ormaintaining in viral latency. In one aspect, the invention provides vaccinesthat contain, or are produced from, viral nucleic acids inwhich the AGG sequences have been mutated. In another aspect, the inventionprovides methods and compositions for affecting thefunction of the AGG motif, and methods for identifying other INS sequences inviral genomes.
